Simon Jones began his career in the trade union movement working for the T&GWU and the Wales TUC. He was Chief Executive of the Wales Co-operative Centre (now Cwmpas) for 10 years and before retiring was the UK Director of Policy and Public Affairs for Marie Curie. He has also worked in the private sector.
He has held a number of public appointments in NHS Wales and outside including being a member of the Charity Commission Board. He has held a number of leadership roles in NHS Wales, first as a member of South Glamorgan Health Authority, then as Vice Chair and Chair of Bro Taf Health Authority, and until December 2008 he was Chair of Cardiff and Vale NHS Trust. During this time, he was lead Trust Chair and also Chair of the Welsh NHS Confederation.